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Publications

Pergolizzi, J., Sardi, A, Pelzar, M. “Merkel Cell Carcinoma: An Aggressive Malignancy”.  American Surgeon 5/97 Vol. 63 Page 450-454.

Pergolizzi, J, Auster M. Conaway G, Sardi A. “Cryosurgery for unresectable primary hepatocellular carcinoma: a case report and review of literature.” Am Surg. May 1999; 65(5): 402-405

Pergolizzi, J, Dobs A. “Essentials Elements of a Clinical Trials Unit/ Center.”  European Pharmaceutical Contractor.  Feb 2000; 3: 96- 99.

Ashkenazy, R, Pergolizzi, J, and Dobs, A. “Organizational model for a clinical trials unit within an academic medical center.”  Research Practitioner Volume 2, Number 2 March/April 2001:107-112

Pergolizzi, J.  PONV Unplugged.  Seminars in Aesthesia, Perioperative Medicine and Pain, Vol 23, No 2 (June), 2004: pp 203-220.

Macario A, Pergolizzi J.  Pain and Nausea Management after Surgery.  The International Journal of Pain and Palliative Care 2004; 3: 91-100.

Macario A, Pergolizzi J. Urine Drug Testing in Chronic Pain Patients Taking Opioids: A Clinical Practice Update.  The International Journal of Pain and Palliative Care 2005; 4(1): 133-9.

Macario, A. and Pergolizzi J.  Systematic literature review of spinal decompression via motorized traction for chronic discogenic low back pain.  Pain Practice. September 2006.Vol. 6 Issue 3 Page 171-178.

Macario A, Claybon L, and Pergolizzi J.  Anesthesiologists’ practice patterns for rescue treatment of postoperative nausea and vomiting in the ambulatory PACU.  BMC Anesthesiology 2006:6:6; (http://www.biomedcentral.com/content/pdf/1471-2253-6-6.pdf)

Davis M., Madia V., Daeninck P., Pergolizzi J. The emerging role of cannabinoid neuromodulators in symptom management. Support Care Cancer (2007) 15: 63–71

Macario A, Richmond C, Auster M, and Pergolizzi J. Treatment of 94 Patients with Chronic Discogenic Back Pain with the DRX9000: A Retrospective Chart Review.  Pain Practice.  January 2008. Vol. 8, Issue 1 Page 11-17.

Pergolizzi J, Boger R, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa R, Sacerdote P. Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone. Pain Practice June 2008.

Pergolizzi J, Florio F, Martin W. Management of low-back pain with a non-surgical spinal decompression system (DRX9000™) – case report, European Musculoskeletal Review, 2008; 3:1; 59–60.

Pergolizzi J, Yochum T, Florio F, Management of discogenic low-back pain with a non-surgical decompression system (DRX9000™)—Case Report, US Musculoskeletal Review, 2008;1:14-15.

Leslie JB, Pergolizzi JV, Macario A, Apfel C, Clair D, Richmond C, Florio, Auster M. Prospective evaluation of the efficacy of spinal decompression via the DRX9000 for chronic low back pain. J Med. September 2008:2–8.

Pergolizzi JV, Clair D, Richmond C. Growth hormone replacement for adults: an overview. J Med. September 2008:9–15.

Pergolizzi J, Richmond C, Auster M, Florio F, Wilhelm J. Non-surgical Spinal Decompression (DRX9000TM) for the Treatment of Chronic Low Back Pain – Case Report, European Musculoskeletal Review, 2008; 3: 2, 58-60.

Sinclair A, Pergolizzi J, Richmond C. Patients Who Smoke: To Cut or Not to Cut. J. Med 2009; 2(1):56-61.

Pergolizzi F, Richmond D, Gan Z, Macario S, Gan TJ, Richmond C, Pergolizzi J. Two-Year Survey of Bullying in American Middle Schools J. Med 2009: 2(1); 45-51.

Groteke E, Pergolizzi J, Chicoine D. The Quantification and Tracking of Osteoarthritis. J. Med 2009; 2(1):23-29.

Pergolizzi J, Claybon L, Macario A, Richmond C. Therapeutic Decision Support and the Management of Post-Operative Nausea and Vomiting.  J. Med 2009; 2(1):62-67

Pergolizzi J, Raffa R. Oxymorphone and Opioid Rotation. Pan Medicine. 2009:10 ;( S1): S39-48.

Gan TJ, Sinha A, Kovac A, Jones K, Cohen S, Battikha J, Deutsch J, and Pergolizzi, J. A Randomized, Double-Blind, Multicenter Trial Comparing Transdermal Scopolamine Plus Ondansetron to Ondansetron Alone for the Prevention of Postoperative Nausea and Vomiting in the Outpatient Setting.  Anesth Analg 2009; 108:1498 –504.

Pergolizzi J, Mercadante S, Virizuela Echaburuc A, Van den Eyndend B, de Farı´a Fragosoe RM, Mordarskif S, Lybaertg W, Beniakh J, Oron´ skai A, and Slamaj O.  The role of transdermal buprenorphine in the treatment of cancer pain: an expert panel consensus. Current Medical Research and Opinion 25:6:  2009, 1517–1528.

Pergolizzi J, Raffa, R, and Gould, E.  Considerations on the use of oxymorphone in geriatric patients Expert Opin. Drug Saf. (2009) 8(5).

Pergolizzi J and Raffa, R. The Use of High-Dose Transdermal Buprenorphine in the Treatment of Cancer Pain.  J. Med 2009; 2(2):111–120.

Varrassi‌ G, Müller-Schwefe‌, Pergolizzi J‌, Orónska A, Morlion B, Mavrocordatos Margarit C, Mangas‌, Jaksch W, Huygen‌, Collett B, Berti M‌, Aldington, Ahlbeck K. Pharmacological treatment of chronic pain – the need for CHANGE. Current Medical Research and Opinion 2010: 26(5): 1231-1245.

Singla NK, Singla SK, Chung, F, Kutsogiannis DJ, Blackburn L, Lane SR, Levin J, Johnson B, Pergolizzi, J.   Phase II Study to Evaluate the Safety and Efficacy of the Oral Neurokinin-1 Receptor Antagonist Casopitant (GW679769) Administered with Ondansetron for the Prevention of Postoperative and Post discharge Nausea and Vomiting in High-risk Patients Anesthesiology 2010; 113:1–1.

Pergolizzi J, Pappagallo M, Stauffer J, Gharibo C, Fortner N, De Jesus MN, Brennan MJ, Richmond C, Hussey D; The Integrated Drug Compliance Study Group (IDCSG).  The Role of Urine Drug Testing for Patients on Opioid Therapy.  Pain Pract. 2010; 10(6):497-507.

Morlion B, Pergolizzi J, Raffa R.  European perspectives on upcoming analgesics: What do they have that we don’t—and what do they think about them? Techniques in Regional Anesthesia and Pain Management 2010:14; 86-98.

Pergolizzi J, Pappagallo M, Raffa R, Gharibo C, Phillips R, Desjonquères S, and Tabor A. Preliminary Observations of a Novel Topical Oil with Analgesic Properties for Treatment of Acute and Chronic Pain Syndromes. Pain Practice 2010:3; 201-213.

Arbuck D, Gharibo C, Labhsetwar S,  Berdos F, Pergolizzi J. Management of Opioid Tolerability and Related Adverse Effects.  Journal of Medicine 2010; 3(1):1–10.

Hochman JS, Pergolizzi J. Cohort study finds nine times increased overdose risk (fatal plus non-fatal) in patients receiving 100 mg/day for 90 days compared with 1-20 mg/day opioids for chronic non-cancer pain, but wide CI and possibility of unmeasured confounders. Evid Based Nurs. 2010; 13(2):55-6.

Raffa RB, Pergolizzi JV, Segarnick DJ and Tallarida RJ. Oxycodone combinations for Pain Relief.  Drugs of Today 2010, 46(6): 379-398.

Apfel CC, Cakmakkaya OS, Martin W, Richmond C, Macario A, George E, Schaefer M and Pergolizzi JV. Restoration of disc height through non-invasive spinal decompression is associated with decreased discogenic low back pain: a retrospective cohort study.  BMC Musculoskeletal Disorders 2010, 11:155doi:10.1186/1471-2474-11-155.

Raffa RB, Pergolizzi JV, and Tallarida RJ. The Determination and Application of Fixed-Dose Analgesic Combinations for Treating Multimodal Pain. The Journal of Pain, 2010: 11(8): 701-709.

Langley P, Muller-Schwerfe G, Liedgens H, Pergolizzi J, Varrassi G. The societal impact of pain in the European Union: health-related quality of life and healthcare resource utilization.  Journal of Medical Economics Vol. 13, No. 3, 2010: 571-581.

Raffa RB and Pergolizzi, J.  Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example. In Press: Journal of Clinical Pharmacy and Therapeutics (2010).

Pergolizzi J, Labhsetwar S,  Puenpatom A, Joo S,  Ben-Joseph R, Summers K. Prevalence of Exposure to Potential CYP450 Pharmacokinetic Drug – Drug Interactions among Patients with Chronic Low Back Pain Taking Opioids. Pain Practice Article first published online: 26 AUG 2010 DOI: 10.1111/j.1533-2500.2010.00413.x

Raffa, RB and Pergolizzi, JV. Opioid Formulations Designed to Resist/Deter Abuse Drugs. 70(13):1657-1675, September 10, 2010.

Langley P,  Mueller-Schwefe G, Nicolaou A, Liedgens H, Pergolizzi J, and Varrassi G. The impact of pain on labor force participation, absenteeism and presenteeism in the European Union. Journal of Medical Economics Vol. 13, No. 4, 2010, 662–672.

Apfel C, Zhang K, George E, Shi S, Jalota L, Hornuss C, Fero K, Heidrich F, Pergolizzi J, Cakmakkaya O, and Kranke P. Transdermal Scopolamine for the Prevention of Postoperative Nausea and Vomiting:  A Systematic Review and Meta-Analysis.  Clinical Therapeutics.  Vol. 32, No.12, 2010, 1-15.

Müller-Schwefe, Jaksch W, Morlion B, Kalso E, Schafer M, Coluzzi F, Huygen F, Kocot-Kepska M, Mangas AC, Margarit C, Ahlbeck K, Orónska A, Mavrocordatos Collett B, Aldington, Nicolaou A, Pergolizzi J‌, Varrassi‌ G. Commentary Make a CHANGE: optimizing communication and pain management decisions. Current Medical Research & Opinion Vol., No. , 2011, 1–8

Raffa RB, and Pergolizzi J. The evolving understanding of the analgesic mechanism of action of flupirtine.  Journal of Clinical Pharmacy and Therapeutics (2010) Article first published online: 28 NOV 2010 DOI: 10.1111/j.1365-2710.2010.01233.x

Pergolizzi F, Pergolizzi J III, Gan Z, Macario S, Pergolizzi JV,  Ewin TJ, and Gan TJ. Bullying in middle school: Results from a 2088 survey. Int J Adolesc Med Health 2011; 23(1):11–18.

Leslie JB, Viscusi ER, Pergolizzi JV, and Panchal SJ.  Anesthetic Routines: The Anesthesiologist’s Role in GI Recovery and Postoperative Ileus Advances in Preventive Medicine Volume 2011, Article ID 976904, 10 pages doi:10.4061/2011/976904 (http://downloads.sage-hindawi.com/journals/apm/2011/976904.pdf)

Pergolizzi JV, Labhsetwar SA, Puenpatom RA, Joo S, Ben-Joseph R and Summers KH. Exposure to Potential CYP450 Pharmacokinetic Drug–Drug Interactions among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions. Pain Practice Article first published online: 28 DEC 2010, DOI: 10.1111/j.1533-2500.2010.00438.x

Altorjay A; Melson T; Chinachoit T;Kett A; Aqua K; Levin J; Blackburn LM; Lane S; Pergolizzi JV.  Casopitant and Ondansetron for Postoperative Nausea and Vomiting Prevention in Women at High Risk for Emesis: A Phase 3 Study. Arch Surg. 2011; 146(2):201-206. doi:10.1001/archsurg.2010.327

Pergolizzi, J.  In response: urine drug screening and compliance. Pain Pract. 2011 Mar; 11(2):199. Doi: 10.1111/j.1533-2500.2011.00443_2.x.

Pergolizzi J, Gan TJ, Plavin S, Labhsetwar S, Taylor R, “Perspectives on the Role of Fospropofol in the Monitored Anesthesia Care Setting,” Anesthesiology Research and Practice, vol. 2011, Article ID 458920, – pages, 2011. doi:10.1155/2011/458920.

Pergolizzi J, Taylor R, and Raffa R.  “Extended-release Formulations of Tramadol in the Treatment of Chronic Pain” In Press: Expert Opin Pharmacother. 2011:12 (11):

Raffa RB and Pergolizzi J.  “Multi-mechanistic analgesia for opioid-induced hyperalgesia.” Journal of Clinical Pharmacy and Therapeutics, 2012, 37, 125–127.

Pergolizzi JV, Raffa RB, Tallarida R, Taylor R, Labhsetwar SA. Continuous Multimechanistic Postoperative Analgesia: A Rationale for Transitioning from Intravenous Acetaminophen and Opioids to Oral Formulations. Pain Pract. 2011 Jun 16. Doi: 10.1111/j.1533-2500.2011.00476.x.

Pergolizzi J, Raffa R, and Taylor R. Prophylaxis of Postoperative Nausea and Vomiting in Adolescent Patients: A Review with Emphasis on Combination of Fixed-Dose Ondansetron and Transdermal Scopolamine.  Journal of Drug Delivery Volume 2011, Article ID 426813, 7 pages doi:10.1155/2011/426813.

Pergolizzi J, Alon E,  Baron R,  Bonezzi C,  Dobrogowski J,  Gálvez R,  Jensen T, Kress HG,  Marcus MAE,  Morlion B,  Perrot S,  Treede RD.  Tapentadol in the management of chronic low back pain: a novel approach to a complex condition?  Journal of Pain Research 2011:4: 203–210.

Pergolizzi J, Alegre C, Blake D, Alén JC, Caporali R, Casser HR, Correa-Illanes G, Fernandes P, Galilea E, Jany R, Jones A, Mejjad O, Morovic-Vergles J, Oteo Álvaro A, Radrigán Araya FJ, Simões ME, Uomo G. Current Considerations for the Treatment of Severe Chronic Pain: The Potential for Tapentadol. Pain Pract. 2011 Jul 29. Doi: 10.1111/j.1533-2500.2011.00487.x.

Varrassi G, Collett B, Morlion B, Kalso E, Nicolaou A, Dickenson A, Pergolizzi J, Schafer M, and Muller-Schwefe G. Conference report Proceedings of the CHANGE PAIN Expert Summit in Rome, June 201. Current Medical Research & Opinion 2011: 27 (10):  2061–2062.

Blair R, Taylor R, Pergolizzi J, Tabor A. Clinical Roundup: How Do You Treat Premenstrual Syndrome in Your Practice?  Alternative and Complementary Therapies. August 2011, 17(4): 237-246. doi:10.1089/act.2011.17401.

Pergolizzi J. Chronic pain – moving from symptom control to mechanism-based treatment.  Current Medical Research & Opinion 2011: 27(10): 2079–2080.

Pergolizzi J. Quantifying the Impact of Drug-Drug Interactions Associated with Opioids. The American Journal of Managed Care. 2011:17 (11). (S) 288-292.

Taylor R, Raffa R, and Pergolizzi J. Naltrexone extended-release injection: an option for the management of opioid abuse.  Substance Abuse and Rehabilitation 2011:2; 219–226.

Pergolizzi J, Ahlbeck K, Aldington D, Alon E, Collett B, Coluzzi F, Huygen F, Jaksch W, Kocot-Kępska M, Mangas AC, Margarit C, Mavrocordatos P, Morlion B, Müller-Schwefe G, Nicolaou A, Hernández CP, Sichere P, Varrassi G.   The chronic pain conundrum: should we CHANGE from relying on past history to assessing prognostic factors? Curr Med Res Opin. 2011 Dec 19.

Taylor R, Lemtouni S, Weiss K, Pergolizzi J. “Pain Management in the Elderly: An FDA Safe Use Initiative Expert Panel’s View on Preventable Harm Associated with NSAID Therapy,” Current Gerontology and Geriatrics Research, vol. 2012, Article ID 196159, 9 pages, 2012. doi:10.1155/2012/196159.

Raffa RB, Pergolizzi JV Jr.  Intracerebroventricular opioids for intractable pain .Br J Clin Pharmacol. 2012 Feb 1. Doi: 10.1111/j.1365-2125.2012.04201.x. [Epub ahead of print]

Pergolizzi J, Raffa R, Taylor R.   Low-dose transdermal buprenorphine system: an update.  Paineurope 2012: 1; 8-9.

Raffa RB, Tallarida RJ, Taylor R Jr, Pergolizzi JV Jr. Fixed-dose combinations for emerging treatment of pain.  Expert Opin Pharmacother. 2012 Mar 16

Raffa RB, Burmeister JJ, Yuvasheva E, Pergolizzi JV Jr. QTc interval prolongation by d-propoxyphene: what about other analgesics? Expert Opin Pharmacother. 2012 May 9. [Epub ahead of print]

Taylor R Jr, Raffa RB, Pergolizzi JV Jr. Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature. J Pain Res. 2012; 5:77-87. Epub 2012 Apr 23.

Raffa RB, Pergolizzi JV Jr. Is Morphine Medicine’s Biggest Misnomer? (July/August). Ann Pharmacother. 2012 Jul 3. [Epub ahead of print]

Angeletti C, Guetti C, Papola R, Petrucci E, Ursini ML, Ciccozzi A, Masi F, Russo MR, Squarcione S, Paladini APergolizzi J, Taylor R Jr, Varrassi G, Marinangeli F.  Pain after earthquake. Scand J Trauma Resusc Emerg Med. 2012 Jun 29; 20(1):43. [Epub ahead of print]

Pergolizzi JV, Raffa RB, Pergolizzi JS, Taylor R. Non-Analgesic Effects of Opioids: Factors Relevant to Opioid Abuse and Abuse-Deterrent Formulations. Curr Pharm Des. 2012 Jun 28. [Epub ahead of print]

Pergolizzi JV Jr, Raffa RB, Taylor R Jr, Rodriguez G, Nalamachu S, Langley P.  A Review of Duloxetine 60 mg Once-Daily Dosing for the Management of Diabetic Peripheral Neuropathic Pain, Fibromyalgia, and Chronic Musculoskeletal Pain Due to Chronic Osteoarthritis Pain and Low Back Pain.  Pain Pract. 2012 Jun 21. Doi: 10.1111/j.1533-2500.2012.00578.x. [Epub ahead of print]

Pergolizzi JV Jr, Gharibo C, Passik S, Labhsetwar S, Taylor R Jr, Pergolizzi JS, Müller-Schwefe G.   Dynamic risk factors in the misuse of opioid analgesics.  J Psychosom Res. 2012 Jun; 72(6):443-51. Epub 2012 Apr 5.

Pergolizzi JV Jr, Philip BK, Leslie JB, Taylor R Jr, Raffa RB. Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting.   J Clin Anesth. 2012 Jun; 24(4):334-45.

Daitch J, Frey ME, Silver D, Mitnick C, Daitch D, Pergolizzi J.  Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine. Pain Physician. 2012 Jul; 15(3 Suppl):ES59-66.

Pergolizzi, Van de Laar M, Langford R, Mellinghoff HU, Merchante IM, Nalamachu S,  O’Brien J, Perrot S, and Raffa RB. Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain Journal of Pain Research 2012:5 327–346

Angeletti C, Guetti C, Papola R, Petrucci E, Ursini ML, Ciccozzi A, Masi F, Russo MR, Squarcione S, Paladini A, Pergolizzi J, Taylor R Jr, Varrassi G, Marinangeli F.  Pain after earthquake. Scand J Trauma Resusc Emerg Med. 2012 Jun 29; 20:43

Taylor R Jr, Pergolizzi JV, Sinclair A, Raffa RB, Aldington D, Plavin S, Apfel CC. Transversus Abdominis Block: Clinical Uses, Side Effects, and Future Perspectives. Pain Pract. 2012 Sep 12. Doi: 10.1111/j.1533-2500.2012.00595.x. [Epub ahead of print]

Raffa RB, Pergolizzi JV, Muniz E, Taylor R, and Pergolizzi J. Designing Opioids That Deter Abuse Pain Research and Treatment 2012, Article ID 282981, 10 pages doi:10.1155/2012/282981

Yarlas A, Miller K, Wen W, Dain B, Lynch SY, Pergolizzi J, Raffa R, Ripa S. A Randomized, Placebo-Controlled Study of the Impact of the 7-Day Buprenorphine Transdermal System on Health-Related Quality of Life in Opioid-Naïve Patients with Moderate-to-Severe Chronic Low Back Pain. The Journal of Pain, Vol 13 No (1), 2013: pp 14-23.

Pergolizzi J, Taylor  R, Plancarte R, Muniz E. Es la Buprenorfina una buena opción en el manejo de dolor postoperatorio? Rev Soc Esp Dolor 2012; 19(6): X-X

Pergolizzi, JV. Treatment of Chronic Pain in Older People: Evidence-Based Choice of Strong-Acting Opioids. Drugs Aging. 2012:12 (29): 993-95.

Pergolizzi JV Jr, Labhsetwar S, Lequang JA. Compounding Pharmacies: Who is in Charge?  Pain Pract. 2013 Jan 28. Doi: 10.1111/papr.12033. [Epub ahead of print]

Taylor R, Pergolizzi JV, Raffa RB. Tapentadol extended release for chronic pain patients. Adv Ther. 2013 Jan; 30(1):14-27. Doi: 10.1007/s12325-013-0002-y. Epub 2013 Jan 15.

van Laar M, Pergolizzi JV Jr, Mellinghoff HU, Merchante IM, Nalamachu S, O’Brien J, Perrot S, Raffa RB  Pain treatment in arthritis-related pain: beyond NSAIDs.  Open Rheumatol J. 2012; 6:320-30. Doi: 10.2174/1874312901206010320. Epub 2012 Dec 13.

Pergolizzi JV, Raffa RB, Taylor R, Nagar S, Labhsetwar S, Sinclair N, Gould EM. An open-label pharmacokinetic study of oxymorphone extended release in the presence of naltrexone in the older adult. J Opioid Manag. 2012 Nov-Dec; 8(6):383-93. Doi: 10.5055/jom.2012.0138

Obrien J, Pergolizzi J, van de Laar M, Mellinghoff HU, Moron Merchante I, Nalamachu S, Perrot S, Raffa RB. Fixed-dose combinations at the front line of multimodal pain management: perspective of the nurse-prescriber. Nursing: Research and Reviews 2013:3

Apfel CC, Turan A, Souza K, Pergolizzi J, Hornuss C  Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysisPain. 2013 Jan 11. pii: S0304-3959(13)00009-2. Doi: 10.1016/j.pain.2012.12.025. [Epub ahead of print]

Taylor R, Pergolizzi J, Porreca F, Raffa R. Opioid antagonists for pain. Expert.  Opin. Investig. Drugs (2013) 22(4).

Merchante I, Pergolizzi J, van de Laar M, Mellinghoff HU, Nalamachu S, O’Brien J, Perrot S, and Raffa RB.   Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review.   ISRN Family Medicine, vol. 2013, Article ID 638469, 15 pages, 2013. doi:10.5402/2013/638469.

Leslie JB, Raffa RB, Taylor R, Muniz E, Nalamachu S, Pergolizzi JV.  Essential Oxygen Oil for Treatment of Sport-Related Injuries American Journal of Sports Science and Medicine, 2013, Vol. 1, No. 1, 7-12

Pergolizzi JV. Treatment of chronic pain in older people: evidence-based choice of strong-acting opioids. Drugs Aging. 2012 Dec; 29(12):993-5; author reply 997-8. Doi: 10.1007/s40266-012-0025-0

Pergolizzi J, Ben Joseph R, Chang CL, Pierz K, Shah D, Hess G Impact of dosage strength on medication persistence among patients treated with buprenorphine transdermal system. Value Health. 2013 May; 16(3):A120. Doi: 10.1016/j.jval.2013.03.576. Epub 2013 May 3.

Pergolizzi J, Hess G, Chang CL, Shah D, Pierz K, Benjoseph R Factors predicting medication persistence among patients initiating Buprenorphine transdermal system. Value Health. 2013 May; 16(3):A120. Doi: 10.1016/j.jval.2013.03.575. Epub 2013 May 3.

Vadivelu N, Gowda AM, Urman RD, Jolly S, Kodumudi V, Maria M, Taylor R Jr, Pergolizzi J.  Ketorolac tromethamine – routes and clinical implications. Pain Pract. 2015 Feb; 15(2):175-93. Doi: 10.1111/papr.12198. Epub 2014 Apr 16.

Pergolizzi JV Jr, Ben-Joseph R, Chang CL, Hess G.  US practitioner prescribing practices and patient characteristics of those newly treated with a buprenorphine transdermal patch system. Curr Med Res Opin. 2014 Aug; 30(8):1579-87. Doi: 10.1185/03007995.2014.901941. Epub 2014 Apr 4.

Summers K, Pergolizzi J, Ma L, Foster D, Overholser B, Sowinski K. The prevalence of opioid-related major potential drug-drug interactions and their impact on health care costs.  Value Health. 2013 May; 16(3):A12. Doi: 10.1016/j.jval.2013.03.076. Epub 2013 May 3.

Pergolizzi JV Jr, Ma L, Foster DR, Overholser BR, Sowinski KM, Taylor R Jr, Summers KH . The prevalence of opioid-related major potential drug-drug interactions and their impact on health care costs in chronic pain patients. J Manag Care Spec Pharm. 2014 May; 20(5):467-76.

Angeletti C, Guetti C, Ursini ML, Taylor R Jr, Papola R, Petrucci E, Ciccozzi A, Paladini A, Marinangeli FPergolizzi J, Varrassi G.  Low Back Pain in a Natural Disaster.  Pain Pract. 2013 Jun 14. Doi: 10.1111/papr.12087. [Epub ahead of print]

Pergolizzi J, Ahlbeck K, Aldington D, Alon E, Coluzzi F, Dahan A, Huygen F, Kocot-Kępska M, Mangas AC, Mavrocordatos P, Morlion B, Müller-Schwefe G,Nicolaou A, Pérez Hernández C, Sichère P, Schäfer M, Varrassi G.  The development of chronic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment. Curr Med Res Opin 2013 Jul 3. [Epub ahead of print]

Pergolizzi JV Jr, Lequang JA. Abuse-Deterrent Formulations of Opioid Analgesics. Pain Pract. 2013 Aug 6. Doi: 10.1111/papr.12093

Raffa RB, Pergolizzi JV Jr. Opioid-induced hyperalgesia: is it clinically relevant for the treatment of pain patients? Pain Manag Nurs. 2013 Sep; 14(3):e67-83.

Raffa RB, Taylor R Jr, Pergolizzi JV Jr Sequestered naltrexone in sustained release morphine or oxycodone – a way to inhibit illicit use? Expert Opin Drug Saf. 2013 Nov 11. [Epub ahead of print]

Pergolizzi JV Jr, Taylor R Jr, Nalamachu S, Raffa RB, Carlson DR, Varanasi RK, Kopecky EA Challenges of treating patients with chronic pain with dysphagia (CPD): physician and patient perspectives. Curr Med Res Opin. 2013 Oct 28. [Epub ahead of print]

Pergolizzi JV Jr, Taylor R Jr, Raffa RB, Nalamachu S, Chopra M.  Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness. Sleep Disord. 2014; 2014:527109. Doi: 10.1155/2014/527109. Epub 2014 Feb 5. Review.

Taylor R Jr, Pergolizzi JV, Raffa RB, Nalamachu S, Balestrieri PJ.  Pain and obesity in the older adult.  Curr Pharm Des. 2014; 20(38):6037-41.

Pergolizzi JV Jr, Raffa RB, Taylor R Jr.  Treating acute pain in light of the chronification of pain. Pain Manag Nurs. 2014 Mar; 15(1):380-90. Doi: 10.1016/j.pmn.2012.07.004. Epub 2012 Aug 25. Review.

Pergolizzi JV, Pappagallo M, LeQuang J, Labhsetwar S, Taylor R. New health care measures: emphasis on better management of postsurgical pain and postoperative nausea and vomiting.  Hosp Pract (1995). 2014 Feb; 42(1):65-74. Doi: 10.3810/hp.2014.02.1093.

Miller K, Yarlas A, Wen W, Dain B, Lynch SY, Ripa SR, Pergolizzi JV Jr, Raffa R. The impact of buprenorphine transdermal delivery system on activities of daily living among patients with chronic low back pain: an application of the international classification of functioning, disability and health.  Clin J Pain. 2014 Dec; 30(12):1015-22. Doi: 10.1097/AJP.0000000000000068.

Raffa RB, Pergolizzi JV Jr.  A modern analgesics pain ‘pyramid’.  J Clin Pharm Ther. 2014 Feb; 39(1):4-6. Doi: 10.1111/jcpt.12110. Epub 2013 Nov 19.

Morley-Forster PK, Pergolizzi JV, Taylor R Jr, Axford-Gatley RA, Sellers EM.   Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum.  J Pain Res. 2013 Dec 4; 6:791-801. Doi: 10.2147/JPR.S47192. Review.

Antor MA, Uribe AA, Erminy-Falcon N, Werner JG, Candiotti KA, Pergolizzi JV and Bergese SD (2014) The effect of transdermal scopolamine for the prevention of postoperative nausea and vomiting. Front. Pharmacol. 5:55. doi: 10.3389/fphar.2014.00055

Nalamachu SR, Pergolizzi J, Taylor R Jr, Slatkin NE, Barrett AC, Yu J, Bortey E, Paterson C, Forbes WP. Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: A Responder Analysis of 2 Randomized, Placebo-Controlled Trials. Pain Pract. 2014 May 10. doi: 10.1111/papr.12218. [Epub ahead of print]

Müller-Schwefe G, Ahlbeck K, Aldington D, Alon E, Coaccioli S, Coluzzi F, Huygen F, Jaksch W, Kalso E, Kocot-Kępska M, Kress HG, Mangas AC, Ferri CM, Morlion B, Nicolaou A, Hernández CP, Pergolizzi J, Schäfer M, and Sichère P. Pain in the cancer patient: different pain characteristics CHANGE pharmacological treatment requirements.  Curr Med Res Opin. 2014 Sep; 30(9):1895-908. doi: 10.1185/03007995.2014.925439. Epub 2014 Jun 10.

Nalamachu S, Pergolizzi JV, Raffa RB, Lakkireddy DR, Taylor R Jr. Drug-drug interaction between NSAIDS and low-dose aspirin: a focus on cardiovascular and GI toxicity. Expert Opin Drug Saf. 2014 Jul; 13(7):903-17. Doi: 10.1517/14740338.2014.924924. Epub 2014 Jun 6. Review.

Galia E, Williams Y, Van Hove B, Pergolizzi J, Etropolski M, Vorsanger G.  Evaluation of the tamper-resistant properties of tapentadol extended-release tablets: results of in vitro laboratory analyses. J Opioid Manag. 2014 May-Jun; 10(3):149-58. Doi: 10.5055/jom.2014.0203.

Raffa RB, Gudin JA, Nalamachu S, Pergolizzi JV Jr. ‘Selective’ COX-1 or COX-2 NSAIDs: time to change a misleading measure.  J Clin Pharm Ther. 2014 Oct; 39(5):455-6. Doi: 10.1111/jcpt.12192. Epub 2014 Jul 29.

Raffa RB, Haidery M, Huang HM, Kalladeen K, Lockstein DE, Ono H, Shope MJ, Sowunmi OA, Tran JK, Pergolizzi JV Jr.  The clinical analgesic efficacy of buprenorphine. J Clin Pharm Ther. 2014 Dec; 39(6):577-83. Doi: 10.1111/jcpt.12196. Epub 2014 Jul 29.

Taylor R, Raffa RB, Pergolizzi JV.  Opioid formulations with sequestered naltrexone: a perspective review.  Ther Adv Drug Saf. 2014 Jun; 5(3):129-37. doi: 10.1177/2042098614526769. Review.

Radnovich R, Chapman CR, Gudin JA, Panchal SJ, Webster LR, Pergolizzi JV Jr. Acute pain: effective management requires comprehensive assessment. Postgrad Med. 2014 Jul; 126(4):59-72. doi: 10.3810/pgm.2014.07.2784.

Smith HS, Raffa RB, Pergolizzi JV, Taylor R, Tallarida RJ. Combining opioid and adrenergic mechanisms for chronic pain. Postgrad Med. 2014 Jul; 126(4):98-114. Doi: 10.3810/pgm.2014.07.2788. Review.

Ciccozzi A, Angeletti C, Guetti C, Pergolizzi J, Angeletti PM, Mariani R, Marinangeli F . Regional anesthesia techniques for carotid surgery: the state of art. J Ultrasound. 2014 May 1; 17(3):175-83. Doi: 10.1007/s40477-014-0094-5. eCollection 2014 Sep.

Daitch D, Daitch J, Novinson D, Frey M, Mitnick C, Pergolizzi J Jr . Conversion from high-dose full-opioid agonists to sublingual buprenorphine reduces pain scores and improves quality of life for chronic pain patients. Pain Med. 2014 Dec; 15(12):2087-94. Doi: 10.1111/pme.12520. Epub 2014 Sep 12.

Langley PC, Pergolizzi JV Jr, Taylor R Jr, Ridgway C. Antioxidant and associated capacities of camu (Myrciaria dubia): a systematic review. J Altern Complement Med. 2015 Jan; 21(1):8-14. Doi: 10.1089/acm.2014.0130. Epub 2014 Oct 2.

Pergolizzi JV, Gharibo C, Ho KY . Treatment Considerations for Cancer Pain: A Global Perspective. Pain Pract. 2014 Dec 3. Doi: 10.1111/papr.12253. [Epub ahead of print]

Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Pergolizzi J, Raffa R, Ripa SR. Buprenorphine transdermal system compared with placebo reduces interference in functioning for chronic low back pain. Postgrad Med. 2015 Jan; 127(1):38-45. Epub 2014 Dec 15.

Yarlas A, Miller K, Wen W, Lynch SY, Ripa SR, Pergolizzi J, Raffa RB. Buprenorphine Transdermal System Improves Sleep Quality and Reduces Sleep Disturbance in Patients with Moderate-to-Severe Chronic Low Back Pain: Results from Two Randomized Controlled Trials. Pain Pract. 2015 Jan 20. Doi: 10.1111/papr.12281. [Epub ahead of print]

Pergolizzi JV, Köknel Talu G, Zmponga G, Erdine S, Taylor R, Ayan B, Raffa RB. Maximizing value in opioid utilization: Is oxycodone immediate release a good option for pain management?  Agri. 2015 Jan; 27(1):1-11. Doi: 10.5505/agri.2015.79663.

Vadivelu N, Gowda AM, Urman RD, Jolly S, Kodumudi V, Maria M, Taylor R Jr, Pergolizzi JV Jr. Ketorolac tromethamine – routes and clinical implications. Pain Pract. 2015 Feb;15(2):175-93. doi: 10.1111/papr.12198. Review.

Pergolizzi JV, Ben-Joseph R, Chang CL, Hess G. Predicting medication persistence to buprenorphine transdermal system. Pain Pract. 2015 Feb;15(2):140-9. doi: 10.1111/papr.12155.

Pergolizzi JV Jr.  DEA reschedules hydrocodone combination products. Pain Pract. 2015 Feb; 15(2):95-7. Doi: 10.1111/papr.12268. No abstract available.

Pergolizzi JV Jr, Zampogna G, Taylor R Jr, Raffa RB. Long-term efficacy, safety and tolerability of Remoxy for the management of chronic pain. Expert Rev Neurother. 2015 Mar; 15(3):231-8. Doi: 10.1586/14737175.2015.1015418. Epub 2015 Feb 15.

Coluzzi F, Pergolizzi J, Raffa RB, Mattia C. The unsolved case of “bone-impairing analgesics”: the endocrine effects of opioids on bone metabolism. Ther Clin Risk Manag. 2015 Mar 31; 11:515-23. Doi: 10.2147/TCRM.S79409. eCollection 2015.

Pergolizzi JV Jr, Taylor R Jr, Raffa RB. Intranasal ketorolac as part of a multimodal approach to postoperative pain. Pain Pract. 2015 Apr; 15(4):378-88. Doi: 10.1111/papr.12239. Epub 2014 Aug 28.

Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Dain B, Pergolizzi JV Jr, Raffa R, Ripa SR. A Subgroup Analysis Found no Diminished Response to Buprenorphine Transdermal System Treatment for Chronic Low Back Pain Patients Classified with Depression. Pain Pract. 2015 Apr 11. Doi: 10.1111/papr.12298. [Epub ahead of print]

Pergolizzi JV Jr, Taylor R Jr, Raffa RB. Intranasal ketorolac as part of a multimodal approach to postoperative pain. Pain Pract. 2015 Apr;15(4):378-88. doi: 10.1111/papr.12239. Review.

Langley PC, Pergolizzi JV Jr, Taylor R Jr, Ridgway C. Antioxidant and associated capacities of Camu (Myrciaria dubia): a systematic review. J Altern Complement Med. 2015 Jan;21(1):8-14. doi: 10.1089/acm.2014.0130. Review.

Vadivelu N, Gowda AM, Urman RD, Jolly S, Kodumudi V, Maria M, Taylor R Jr, Pergolizzi JV Jr. Ketorolac tromethamine – routes and clinical implications. Pain Pract. 2015 Feb;15(2):175-93. doi: 10.1111/papr.12198. Review.

Pergolizzi JV, Ben-Joseph R, Chang CL, Hess G. Predicting medication persistence to buprenorphine transdermal system. Pain Pract. 2015 Feb;15(2):140-9. doi: 10.1111/papr.12155.

Pergolizzi JV Jr, Taylor R Jr, Raffa RB. Intranasal ketorolac as part of a multimodal approach to postoperative pain. Pain Pract. 2015 Apr;15(4):378-88. doi: 10.1111/papr.12239. Review.

Coluzzi F, Raffa RB, Pergolizzi J, Rocco A, Locarini P, Cenfra N, Cimino G, Mattia C. Tapentadol prolonged release for patients with multiple myeloma suffering from moderate-to-severe cancer pain due to bone disease. J Pain Res. 2015 May 8;8:229-38. doi: 10.2147/JPR.S83490.

Eichenbaum G, Göhler K, Etropolski M, Steigerwald I, Pergolizzi J, Kim M, Vorsanger G. Does tapentadol affect sex hormone concentrations differently from morphine and oxycodone? An initial assessment and possible implications for opioid-induced androgen deficiency. J Opioid Manag. 2015 May-Jun;11(3):211-27. doi: 10.5055/jom.2015.0270.

Pergolizzi JV Jr, Taylor R Jr, Raffa RB. The Potential Role of an Extended-Release, Abuse-Deterrent Oxycodone/Acetaminophen Fixed-Dose Combination Product for the Treatment of Acute Pain. Adv Ther. 2015 Jun;32(6):485-95. doi: 10.1007/s12325-015-0213-5.

Pergolizzi JV Jr, Scholten W, Smith KJ, Leighton-Scott J, Willis JC, Henningfield JE. The unique role of transdermal buprenorphine in the global chronic pain epidemic. Acta Anaesthesiol Taiwan. 2015 Jun;53(2):71-6. doi: 10.1016/j.aat.2015.06.001.

Nalamachu SR, Pergolizzi J, Taylor R Jr, Slatkin NE, Barrett AC, Yu J, Bortey E, Paterson C, Forbes WP. Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: A Responder Analysis of 2 Randomized, Placebo-Controlled Trials. Pain Pract. 2015 Jul;15(6):564-71. doi: 10.1111/papr.12218.

Pergolizzi JV Jr. New care measures and their impact on pain medicine: One pain specialist’s perspective. Postgrad Med. 2015 Aug;127(6):616-22. doi: 10.1080/00325481.2015.1054616.

Pergolizzi JV, Köknel Talu G, Zmponga G, Erdine S, Taylor R, Ayan B, Raffa RB. Maximizing value in opioid utilization: Is oxycodone immediate release a good option for pain management? Agri. 2015;27(1):1-11. doi: 10.5505/agri.2015.79663.

Pergolizzi JV, Gharibo C, Ho KY. Treatment Considerations for Cancer Pain: A Global Perspective. Pain Pract. 2015 Nov;15(8):778-92. doi: 10.1111/papr.12253. Review.

Coluzzi F, Mattia C, Savoia G, Clemenzi P, Melotti R, Raffa RB, Pergolizzi JV Jr. Postoperative Pain Surveys in Italy from 2006 and 2012: (POPSI and POPSI-2). Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4261-9.

Meissner W, Coluzzi F, Fletcher D, Huygen F, Morlion B, Neugebauer E, Pérez AM, Pergolizzi J. Improving the management of post-operative acute pain: priorities for change. Curr Med Res Opin. 2015 Nov;31(11):2131-43. doi: 10.1185/03007995.2015.1092122.

Nguyen V, Raffa RB, Taylor R, Pergolizzi JV Jr. The role of abuse-deterrent formulations in countering opioid misuse and abuse. J Clin Pharm Ther. 2015 Dec;40(6):629-34. doi: 10.1111/jcpt.12337. Review.

Li Z, Pergolizzi JV, Huttner RP, Zampogna G, Breve F, Raffa RB. Management of opioid-induced constipation in pregnancy: a concise review with emphasis on the PAMORAs. J Clin Pharm Ther. 2015 Dec;40(6):615-9. doi: 10.1111/jcpt.12331. Review.

Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Dain B, Pergolizzi J, Raffa R, Ripa SR. Buprenorphine Transdermal System Improves Sleep Quality and Reduces Sleep Disturbance in Patients with Moderate-to-Severe Chronic Low Back Pain: Results from Two Randomized Controlled Trials. Pain Pract. 2016 Mar;16(3):345-58. doi: 10.1111/papr.12281.

Pergolizzi J, Zampogna G, Taylor R, Gonima E, Posada J, Raffa RB. A Guide for Pain Management in Low and Middle Income Communities. Managing the Risk of Opioid Abuse in Patients with Cancer Pain. Front Pharmacol. 2016 Mar 1;7:42. doi: 10.3389/fphar.2016.00042. Review.

Pergolizzi J, Raffa RB, Nalamachu S, Taylor R Jr. Evolution to low-dose NSAID therapy. Pain Manag. 2016 Apr;6(2):175-89. doi:10.2217/pmt.15.69.

Coluzzi F, Taylor R Jr, Pergolizzi J Mattia C, Raffa RB, Braz J Good clinical practice guide for opioids in pain management: the three Ts – titration (trial), tweaking (tailoring), transition (tapering). Anesthesiol. 2016 May-Jun; 66 (3):310-7. doi: 10.1016/j.bjane.2014.09.005.

Coluzzi F, Taylor R Jr, Pergolizzi J, Mattia C, Raffa RB. [Good clinical practice guide for opioids in pain management: the three Ts – titration (trial), tweaking (tailoring), transition (tapering).] Rev Bras Anestesiol. 2016 May-Jun; 66 (3):310-7. doi:10.1016/j.bjan.2016.02.008. Portuguese.

Raffa RB, Taylor R Jr, Pergolizzi JV Jr, Nalamachu S, Edwards ES, Edwards ET.  Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Deliv Transl Res. 2016 Aug 25. [Epub ahead of print]

Lin TC, Ger LP, Pergolizzi J, Raffa RB, Wang JO, Ho ST. Knowledge, Attitude and Practice Survey of Prescribing Opioids for Chronic Noncancer Pain in Taiwan-Comparison of Pain and Non-Pain Physicians. Pain Med. 2016 Aug 22. pii: pnw189. [Epub ahead of print]

Pergolizzi J, Raffa RB, Zampogna G, Breve F, Colucci R, Schmidt WK, LeQuang JA. Comments and Suggestions from Pain Specialists Regarding the CDC’s Proposed Opioid Guidelines. Pain Pract. 2016 Sep;16(7):794-808

Pergolizzi JV Jr, Seow-Choen F, Wexner SD, Zampogna G, Raffa RB, Taylor R Jr. Perspectives on Intravenous Oxycodone for Control of Postoperative Pain. Pain Pract. 2016 Sep;16(7):924-34. doi: 10.1111/papr.12345. Review.

Pergolizzi J, Paladini A, Varrassi G, Raffa RB. Change Pain: Ever Evolving-An Update for 2016. Pain Ther. 2016 Oct 14. [Epub ahead of print]

Pergolizzi J, Raffa RB, LeQuang JA. The Centers for Disease Control and Prevention opioid guidelines: potential for unintended consequences and will they be abused? J Clin Pharm Ther. 2016 Dec; 41(6):592-593

Lin TC, Ger LP, Pergolizzi JV Jr. Raffa RB, Wang JO, Ho ST. Long-term use of opioids in 210 officially registered patients with chronic noncancer pain in Taiwan: A cross-sectional study. J Formos Med Assoc. 2016 Dec 23. Doi: 10.1016/j.jma.2016.10.015 (epub ahead of print)

Müller-Schwefe G, Morlion B, Ahlbeck K, Alon E, Coaccioli S, Coluzzi F, Huygen F, Jaksch W, Kalso E, Kocot-Kępska M, Kress HG, Mangas AC, Margarit Ferri C, Mavrocordatos P, Nicolaou A, Hernández CP, Pergolizzi J, Schaefer M, Sichère P. Treatment for chronic low back pain: the focus should change to multimodal management that reflects the underlying pain mechanisms. Curr Med Res Opin 2017 Feb 22: doi: 10.1080/03007995.2017.1298521 (epub ahead of print).

Pergolizzi JV Jr, Taylor R, LeQuang JA, Zampogna G, Raffa RB. Concise review of the management of iatrogenic emesis using cannabinoids: emphasis on nabilone for chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 2017 Mar; 79(3):467-477.

Pergolizzi JV Jr, Raffa RB, Pappagallo M, Fleischer C, Pergolizzi J 3rd, Zampogna G, Duval E, Hismeh J, LeQuang JA, Taylor R Jr. Peripherally acting µ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy. Patient Pref Adherence 2017 Jan 17; 11:107-0119.

Pergolizzi JV, Raffa RB, Marcum Z, Colucci S, Ripa SR. Safety of buprenorphine transdermal system in the management of pain in older adults. Postgrad Med. 2017 Jan; 129(1):92-101.

Raffa RB, Taylor R Jr. Pergolizzi JV Jr, Nalamachu S, Edwards ES, Edwards ET. Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Deliver Transl Res. 2017 Feb; 7(1):1-10.

Broglio K, Pergolizzi J, Kowalski M, Lunch SY, HeE, Wen W. Long-term effectiveness of once-daily, single-entity, extended-release hydrocodone in patients of ≥ 75 years of age with moderate to severe nonmalignant and nonneuropathic pain. Geriatr Nurs. 2017 Jan-Feb; 38(1):39-47.

Broglio K, Pergolizzi J, Kowalski M, Lunch SY, HeE, Wen W. Efficacy and safety of once-daily extended-release (ER) hydrocodone in individuals previously receiving ER morphine for chronic pain. Pain Pract. 2017 Mar; 17(3):382-391.

Pergolizzi JV Jr, Taylor R, LeQuang JA, Zampogna G, Raffa RB. Concise review of the management of iatrogenic emesis using cannabinoids: emphasis on nabilone for chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 2017 Mar;79(3):467-477. doi: 10.1007/s00280-017-3257-1. Epub 2017 Feb 24.